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    [9.16]NS Forum No.173-Nanoparticles as Targeted Drug Delivery Vehicles for Molecular Imaging and Chemotherapy Applications

    Title: Nanoparticles as Targeted Drug Delivery Vehicles for Molecular Imaging and Chemotherapy Applications
    Speaker: Prof. Paul Wang, HOWARD UNIVERSITY
    Host: Prof. Xing-jie Liang
    Time: 9:30 AM, September 16, 2011 

    Place: Conference Room of Second floor in NCNST

    Abstract :

    Nanoparticles, which hold many unique properties, including versatility, tunable size, and highly adaptable surface chemistry, have been used successfully as imaging agents for in vivo imaging of various diseases. Using nanoparticles as imaging agents has significantly improved the detection sensitivity and specificity. Nanoparticles have great potential for early detection of cancer, genetic defects, cardiovascular and neurodegenerative diseases.

    Using nanoparticles as an imaging agent provides new paradigms for every imaging modality: CT, MRI, PET, SPECT, Ultrasound, and Optical Imaging. Each imaging modality differs in detection sensitivity, depth penetration, spatial resolution, temporal resolution, costs, and whether it involves ionization radiation. Various materials, including liposome, dendrimer, micelle, polymer, gold nanoshell, colloidal gold, and fullerene, have been used to compose nanoparticles as imaging agents suitable for different imaging modalities. The physicochemical properties such as size, charge, shape, flexibility, hydrophilicity, and surface modification greatly influence the pharmacokinetics of nanoparticles, affecting their success as imaging agents. The nano-sized imaging agents need to stay within the system for a sufficient time in order to produce the desired image enhancement effects. Reducing exposure to foreign material by optimizing clearance is a central principle for minimizing unwanted effects of any foreign materials within the human body. Nanoparticles are cleared from the vascular compartment through three primary mechanisms: renal clearance with excretion into the urine, hepatic clearance with biliary excretion, or uptake by macrophages into the reticuloendothelial system. For clinical application, renal clearance will be a preferred route for nanoparticles as imaging agents.

    Although many studies have accomplished making nanoparticles to be more effective imaging agents, there are still challenges ahead for nano imaging agents to be translational into routine clinical practice, including further improvement of targeting efficiency and specificity, and how to overcome the associated toxicity to the patients.

    EXPERIENCE:

    2001-    Associate Professor in Radiology Department.
    1999-     HOWARD UNIVERSITY       Washington, DC
    present    Graduate Professor in Department of Biochemistry and Molecular Biology
    2001-     HOWARD UNIVERSITY       Washington, DC
    present    Adjunct Professor in Department of Biochemistry and Molecular Biology
    2001-     HOWARD UNIVERSITY       Washington, DC
    present  Professor in Radiology Department. Director of the Biomedical NMR Laboratory. Primary responsibilities are to coordinate NMR research projects, to provide technical support, and to supervise the operation of NMR center. Research areas include: In vitro and in vivo NMR; NMR imaging and spectroscopy studies of diseases including cancer, heart disease, and degenerative diseases using small animal models; NMR studies of multidrug interaction and body composition; molecular imaging; and NMR applications in agriculture. Since 2005, the research interests also includedeveloping nanoparticles as drug delivery vehicles for targeted therapy and diagnostic imaging.
    2007-   Guest Professor, National Center for Nanoscience and Technology    Beijing, China

    count:
    Copyright © 2011, Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,
    Chinese Academy of Sciences
    Email: zhao-office@ihep.ac.cn