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国家纳米科学中心“用于肿瘤治疗的智能型DNA纳米机器人”入选2018年度中国科学十大进展 |
[2019-02-27]
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| 2019年2月27日，由科技部基础研究管理中心牵头举办的“中国科学十大进展”结果发布，国家纳米科学中心聂广军、丁宝全和赵宇亮研究组与美国亚利桑那州立大学颜灏研究组等合作，研制出用于肿瘤治疗的智能型DNA纳米机器人，入选2018年度中国科学十大进展。
利用纳米医学机器人实现对人类重大疾病的精准诊断和治疗是科学家们追逐的一个伟大的梦想。国家纳米科学中心聂广军、丁宝全和赵宇亮研究组与美国亚利桑那州立大学颜灏研究组等合作，在活体内可定点输运药物的纳米机器人研究方面取得突破，实现了纳米机器人在活体（小鼠和猪）血管内稳定工作并高效完成定点药物输运功能。研究人员基于DNA纳米技术构建了自动化DNA机器人，在机器人内装载了凝血... |
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Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activ... |
[2018-08-30]
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| Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siR... |
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Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor |
[2015-06-01]
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| The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C82(OH)22, while essentially not toxic to normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cancer cells. Gd@C82(OH)22 blocks epithelial-to-mesenchymal transition with resultant efficient elimination of breast cancer stem cells (CSCs) resulting in abrogation of tumour initiation and metastasis. In normoxic conditions, Gd... |
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IHEP project won the 2012 Second-grade National Natural Science Award |
[2013-01-29]
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| The 2012 National Science and Technology Awards Conference was held on January 18, 2013 in the Great Hall of the People in Beijing. The IHEP project of “Health Effects of Nanomaterials and Nanosafety Study” was accredited the Second-grade National Natural Science Award.This project is a multidisciplinary research of bioinorganic chemistry, nanotoxicology and analytical chemistry. The project focused on understanding of the toxicity properties of nanomaterials and their health effects, as well as their relationships with physiochemical properties of nanomaterials, and development of analy... |
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